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To avoid aldosterone-induced oxidative damage, kidney cells were tested for their potential to up-regulate nuclear factor-erythroid-2-related factor 2 (Nrf2) (74)

Inhibition of non-CYP enzymes especially UDP-glucuronosyltransferases (UGTs) significantly predicts high risk for drug-induced liver injury (DILI)

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This copper-binding characteristic is central to the compounds biochemical identity